Immunological changes in DS have been observed since the 1970s
Aluminium oxyhydroxide human vaccines, and the mechanism behind its immune stimulating properties is still poorly understood
Study suggests that there are abnormalities in the cellular arms of the immune response in children with DS and an intrinsic immune deficiency has been provided by a cross-sectional study
One of the most common genetic abnormalities is Down syndrome
A groundbreaking new study conducted by the Crnic Institute for Down Syndrome shows definitively that Down syndrome can be categorized as an immune system disorder.
Hyperactivity of the immune system can be found in multiple parts of the body of someone with Down syndrome.
Suggesting that the underlying pathology is immune dysfunction.
DS individuals may have a high frequency of infections, usually of the upper respiratory tract, characterized by increased severity and prolonged course of disease, which are partially attributed to defects of the immune system.
Evidence of significantly reduced T lymphocyte numbers, both of CD4+ and CD8+ cells in DS has been well studied
Prevalence of autoimmune disorders affecting both endocrine and non-endocrine organs
Individuals with Down syndrome have a high incidence of immunological alterations.
Over-expression of APP induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.
Factors that place patient with Down Syndrome at great risk for infection.
Interferon response is consistently activated in cells obtained from individuals with Down syndrome
Down syndrome is considered one of the most challenging disorders to simulate in laboratory animals. Early attempts at modeling Down syndrome in mice (1974) failed because they died at birth, but in 1990 the Davisson discovery of the Ts65Dn mouse model was somewhat successful and has been used since then to begin to understand this complex disorder.
However, on June 29, 2020 John Hopkins University announced a new mouse replica of DS (TcMAC21)which they reported to eLife Sciences. This new mouse model, using mouse artificial chromosome vectors(MACs), is capable of transferring a nearly complete intact copy of HSA21q and 93% of the protein coding genes (PCGs); meaning that this new humanized mouse is the most complete genetic mouse model for Down Syndrome to date.
Researchers have said that mouse models have been critical to understanding of the molecular genetics of DS. The synteny between human and mouse genomes have allowed researchers to pinpoint the genes responsible for the identification of Down syndrome. (This is simply to identify them, not understand how they work), but researchers also admit that “there is no perfect animal model for a human genetic disease, less-so for a complex syndrome’(DS).
Without animal testing to determine if the Covid19 vaccine safe for complex immune system of DS, they have no evidence that this vaccine will be preventative, or if it will be genocide.
It cannot be understated that without animal trials and testing, it is not possible to determine that any vaccine is safe for children with an intrinsic defect of their immune system. The TcMAC21 mouse and human trials are the only means by which the risk-benefit ratio can be studied to ensure that this vaccine will not cause a cytokine storm in this population.
There are no randomized double-blind, placebo-controlled trials that has included anyone with Down syndrome before making this recommendation, because doing so would be unethical. However, it is equally unethical to test this experimental vaccine directly to this high-risk population who have a known mitochondrial defect of the immune system.
Even if animal trials were conducted for DS using the TcMAC21 mouse, is the CDC telling us that they were able to obtain enough fact-based evidence to determine that the Covid19 vaccine will interact safely in the complex immune system disorder of Down syndrome? Are they saying that they were able to accomplish in seven months what science has not been able to accomplish in over a century?
The CDC must stand behind their pledge to the American people, which is to base all public health decisions on the highest quality scientific data that is derived openly and objective and share this information openly with the 60% of families who provide health care at home for a child with Down syndrome and they have a responsibility to the American public to be diligent stewards of the funds entrusted to their agency and use tax-payer funds to ensure the safety of this vaccine to all Americans who have Down syndrome.
If they cannot demonstrate in any way that this vaccine is safe for this high-risk population, they should retract this recommendation immediately.
In the absence of high-quality scientific data used to determine that the Covid19 vaccine is safe for people with Down syndrome, the CDC has violated the trust of every American with DS and have demonstrated a gross negligence of tax-payer funds by not providing this information openly and available on their website for all parents, doctors and agencies to review, especially during a pandemic.
 https://www.sciencedaily.com/releases/2020/08/200818142130.htm DS most challenging to simulate in laboratory
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358007/ eLife sciences transchromosomic mouse models
 https://www.hindawi.com/journals/np/2012/171639/ critical research using mice
 https://www.nature.com/scitable/topicpage/trisomy-21-causes-down-syndrome-318/ Trisomy21 causes Down syndrome
 https://elifesciences.org/articles/56223 eLife sciences-
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759463/ Intrinsic defect of the immune system in children with DS
 https://www.cdc.gov/ncbddd/birthdefects/downsyndrome/data.html CDC healthcare needs and costs for DS